Watch Intently (1)pentobarbital will lessen the extent or effect of glecaprevir/pibrentasvir by affecting hepatic/intestinal enzyme CYP3A4 metabolism.pentobarbital will lessen the level or result of mestranol by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Watch.pentobarbital will lower the extent or outcome of solifenacin b